Pesticides and Parkinson's Disease.qxp
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چکیده
Even basic epidemiological information remains uncertain. Prevalence and incidence values are difficult to obtain since PD is not a notifiable disease, but it is believed that 1 in every 300 people in Canada and the United States has Parkinson's disease [2]. While genetic susceptibility is believed to play a large role in early-onset PD, most cases of PD seen in North America develop after age 50, suggesting that the majority of PD is caused by a factor other than genetics [3].
منابع مشابه
Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease.
PURPOSE The manifestation of Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, and rigidity. The etiology of PD remains unknown. Recently several studies suggest that some environmental and genetic factors may be related to the cause of PD. Genetic variation in xenobiotic metabolizing enzymes involved in the disposition of pesticides, such as paraoxonase I (PON 1), may ...
متن کاملPesticide exposure and Parkinson's disease: BfR sees association but no causal relationship - BfR Expert Opinion No. 033/2006, 27 June 2006
Parkinson's is a slow progressive neurodegenerative disorder which mainly occurs in later life. In the course of this disease the brain cells that produce the messenger substance, dopamine, die off. This important neurotransmitter conducts impulses between the nerves. If insufficient quantities are present, then the typical symptoms of Parkinson's like muscle rigidity, muscle tremor or loss of ...
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The current study used Department of Veteran's Affairs (VA) clinical records, State of California pesticide application records, spatial maps of distribution of Parkinson's disease patients, and pesticide applications to determine if there was evidence for "blow-in" of pesticides as a factor in explaining the prevalence of Central Valley Parkinson's disease. The results did not support the hypo...
متن کاملEnvironmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study.
OBJECTIVE To investigate the associations between Parkinson's disease and other degenerative parkinsonian syndromes and environmental factors in five European countries. METHODS A case-control study of 959 prevalent cases of parkinsonism (767 with Parkinson's disease) and 1989 controls in Scotland, Italy, Sweden, Romania and Malta was carried out. Cases were defined using the United Kingdom P...
متن کاملResidential Pesticide Usage in Older Adults Residing in Central California
Information on residential pesticide usage and behaviors that may influence pesticide exposure was collected in three population-based studies of older adults residing in the three Central California counties of Fresno, Kern, and Tulare. We present data from participants in the Study of Use of Products and Exposure Related Behaviors (SUPERB) study (N = 153) and from community controls ascertain...
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